Cefix® 200 mg
capsule: Each capsule contains 200 mg Cefixime (trihydrate).
Cefix® 400 mg
capsule: Each capsule contains 400 mg Cefixime (trihydrate).
Cefix® 100 mg
suspension: Each 5 ml contains 100 mg Cefixime (trihydrate).
Cefix® is a broad
spectrum semi-synthetic third generation cephalosporin for oral administration.
The bactericidal action results from inhibition of cell wall synthesis. Cefix®
is highly beta-lactamase stable, which makes it effective against many
organisms resistant to penicillins and some cephalosporins.
Cefix® is active
against the following Gram-positive and Gram-negative organisms:
pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Haemophilus
influenzae, Haemophilus parainfluenzae, Moraxella (Branhamella) catarralis,
Escherichia coli, Proteus mirabilis, Proteus vulgaris, Neisseria gonorrhoeae,
Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia
species, Shigella species, Citrobacter diversus, Serratia marcescens.
indicated in the treatment of the following infections:
- Pharyngitis, tonsillitis and
- Acute bronchitis and acute
exacerbation of chronic bronchitis.
- Otitis media.
- Uncomplicated urinary tract
- Uncomplicated cervical or
Usual adult dose: 400 mg
daily, this may be given as 400 mg once daily or 200 mg every 12 hours.
the treatment of uncomplicated urethral or cervical gonococcal infections,
400mg as single dose is recommended.
Usual pediatric dose:
8mg/kg/day of suspension. This may be given as single dose or in two divided
doses as 4mg/kg/12 hours.
following table shows children dose:
Patient weight (kg)
Dose / day (mg)
Dose / day (ml)
weighing more than 50 kg or older than 12 years should be treated with the
recommended adult dose.
in renal impairment
cases of renal impairment, the dosage should be adjusted according to the
the creatinine clearance more than or equals 60 ml / min., the standard dose of
400 mg can be given, if it ranges from 21- 60 ml/min., 75% of the standard dose
can be given and in cases where it is less than 20ml / min., half the standard
dose can be given.
Cefixime is contraindicated in patients who had
previous hypersensitivity reactions to any of cephalosporins antibiotics
Cefix® has mild
and transient side effects such as diarrhea, nausea, vomiting, abdominal pain,
skin rashes, urticaria and transient elevation in liver enzymes.
of these adverse effects may occur:
and Lymphatic Systems:
As with other antibiotics,
prolonged use may result in overgrowth of non-susceptible organisms.
interaction with warfarin and anticoagulant may occur.
no specific antidote exists, gastric lavage may be indicated.
in pregnancy and lactation
category B: this drug should be used during pregnancy only if clearly needed.
is not known whether cefixime is
excreted in breast milk, yet no problems in humans have been reported to date.
Cefix® 200 mg capsule:
8 capsules per pack.
Cefix® 400 mg
capsule: 5 capsules per pack.
Cefix® 100 mg
suspension: 30, 60 ml bottle.